Supplemental Amino Acids: Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Threonine, Tryptophan, Tyrosine, Valine
Leucine is an essential amino acid and one of the branched-chain amino acids (the others are isoleucine and valine). These work together to protect muscle and act as fuel. They promote the healing of bones, skin, and muscle tissue, and are recommended for those recovering from surgery. Leucine also lowers elevated blood sugar levels and aids in increasing growth hormone production.
Natural sources of leucine include brown rice, beans, meat, nuts, soy flour, and whole wheat. Supplemental L-leucine must be taken in balance with L-isoleucine and L-valine (see Isoleucine in this section), and it should be taken in moderation, or symptoms of hypoglycemia may result. An excessively high intake of leucine may also contribute to pellagra, and may increase the amount of ammonia present in the body.
Lysine is an essential amino acid that is a necessary build-ing block for all protein. It is needed for proper growth and bone development in children; it helps calcium absorption and maintains a proper nitrogen balance in adults. This amino acid aids in the production of antibodies, hormones, and enzymes, and helps in collagen formation and tissue repair. Because it helps to build muscle protein, it is good for those recovering from surgery and sports injuries. It also lowers high serum triglyceride levels.
Methionine is an essential amino acid that assists in the breakdown of fats, thus helping to prevent a buildup of fat in the liver and arteries that might obstruct blood flow to the brain, heart, and kidneys. The synthesis of the amino acids cysteine and taurine may depend on the availability of methionine. This amino acid helps the digestive system; helps to detoxify harmful agents such as lead and other heavy metals; helps diminish muscle weakness, prevent brittle hair, and protect against radiation; and is beneficial for people with osteoporosis or chemical allergies. It is useful also in the treatment of rheumatic fever and toxemia of pregnancy.
Methionine is a powerful antioxidant. It is a good source of sulfur, which inactivates free radicals and helps to prevent skin and nail problems. It is also good for people with Gilbert’s syndrome, an anomaly of liver function, and is required for the synthesis of nucleic acids, collagen, and proteins found in every cell of the body. It is beneficial for women who take oral contraceptives because it promotes the excretion of estrogen. It reduces the level of histamine in the body, which can be useful for people with schizophrenia, whose histamine levels are typically higher than normal.
As levels of toxic substances in the body increase, the need for methionine increases. The body can convert methionine into the amino acid cysteine, a precursor of glu-tathione. Methionine thus protects glutathione; it helps to prevent glutathione depletion if the body is overloaded with toxins. Since glutathione is a key neutralizer of toxins in the liver, this protects the liver from the damaging effects of toxic compounds.
Ornithine helps to prompt the release of growth hormone, which promotes the metabolism of excess body fat. This effect is enhanced if ornithine is combined with arginine and carnitine. Ornithine is necessary for proper immune-system and liver function. This amino acid also detoxifies ammonia and aids in liver regeneration. High concentrations of ornithine are found in the skin and connective tissue, making it useful for promoting healing and repairing damaged tissues.
Ornithine is synthesized in the body from arginine, and in turn serves as the precursor of citrulline, proline, and glutamic acid. Children, pregnant women, nursing mothers, or anyone with a history of schizophrenia should not take supplemental L-ornithine, unless they are specifically directed to do so by a physician.
Phenylalanine is an essential amino acid. Because it can cross the blood-brain barrier, it can have a direct effect on brain chemistry. Once in the body, phenylalanine can be converted into another amino acid, tyrosine, which in turn is used to synthesize two key neurotransmitters that pro-mote alertness: dopamine and norepinephrine. Because of its relationship to the action of the central nervous system, this amino acid can elevate mood, decrease pain, aid in memory and learning, and suppress the appetite. It can be used to treat arthritis, depression, menstrual cramps, mi-graines, obesity, Parkinson’s disease, and schizophrenia.
Phenylalanine is available in three different forms, designated L-, D-, and DL-. The L- form is the most common type and is the form in which phenylalanine is incorporated into the body’s proteins. The D- form acts as a painkiller. The DL- form is a combination of the D- and the L-. Like the D- form, it is effective for controlling pain, especially the pain of arthritis; like the L- form, it functions as a building block for proteins, increases mental alertness, suppresses the appetite, and helps people with Parkinson’s disease. It has been used to alleviate the symptoms of premenstrual syndrome (PMS) and various types of chronic pain.
Supplemental phenylalanine, as well as products containing aspartame (an artificial sweetener made from phenylalanine and another amino acid, aspartic acid), should not be taken by pregnant women or by people who suffer from anxiety attacks, diabetes, high blood pressure, phenylketonuria (PKU), or preexisting pigmented melanoma, a type of skin cancer.
Threonine is an essential amino acid that helps to maintain the proper protein balance in the body. It is important for the formation of collagen, elastin, and tooth enamel, and aids liver and lipotropic function when combined with as-partic acid and methionine. A precursor of the amino acids glycine and serine, threonine is present in the heart, central nervous system, and skeletal muscle, and helps to prevent fatty buildup in the liver. It enhances the immune system by aiding in the production of antibodies, and may be helpful in treating some types of depression.
Because the threonine content of grains is low, vegetarians are more likely than others to have deficiencies.
Tryptophan is an essential amino acid that is necessary for the production of vitamin 63 (niacin). It is used by the brain to produce serotonin, a necessary neurotransmitter that transfers nerve impulses from one cell to another and is re-sponsible for normal sleep. Consequently, tryptophan helps to combat depression and insomnia and to stabilize moods.
Tryptophan helps to control hyperactivity in children, alleviates stress, is good for the heart, aids in weight control by reducing appetite, and enhances the release of growth hormone. It is good for migraine headaches and may reduce some of the effects of nicotine. Sufficient amounts of vitamins Bg (pyridoxine) and C, folate, and magnesium are necessary for the formation of tryptophan, which, in turn, is required for the formation of serotonin. A study reported in the Archives of General Psychiatry found that women with a history of bulimia nervosa, an eating disorder, experienced relapses after they took an amino acid mixture lacking tryptophan. Researchers believe that insufficient tryptophan altered brain serotonin levels and, consequently, the transmission of nerve impulses. A lack of tryptophan and magnesium may contribute to coronary artery spasms.
The best dietary sources of tryptophan include brown rice, cottage cheese, meat, peanuts, and soy protein. This amino acid is not available in supplement form in the United States. In November 1989, the U.S. Centers for Disease Control reported evidence linking L-tryptophan supplements to a blood disorder called eosinophiliamyalgia syndrome (EMS).
Several hundred cases of this illness which is characterized by an elevated white blood cell count and can also cause such symptoms as fatigue, muscular pain, respiratory ailments, edema, and rash were reported. After the CDC established an association between the blood disorder and products containing L-tryptophan in New Mexico, the U.S. Food and Drug Administration first warned consumers to stop taking L-tryptophan supplements, then recalled all products in which L-tryptophan was the sole or a major component.
Subsequent research showed that it was contaminants in the supplements, not the tryptophan, that was probably responsible for the problem, but tryptophan supplements are still banned from the market in the United States.
According to the FDA, at least thirty-eight deaths were attributable to the tryptophan supplements.
Tyrosine is important to overall metabolism. It is a precursor of adrenaline and the neurotransmitters norepinephrine and dopamine, which regulate mood and stimulate metabolism and the nervous system. Tyrosine acts as a mood elevator; a lack of adequate amounts of tyrosine leads to a deficiency of norepinephrine in the brain, which in turn can result in depression. It also acts as a mild antioxidant, suppresses the appetite, and helps to reduce body fat. It aids in the production of melanin (the pigment responsible for skin and hair color) and in the functions of the adrenal, thyroid, and pituitary glands. It is also involved in the metabolism of the amino acid phenylalanine.
Tyrosine attaches to iodine atoms to form active thyroid hormones. Not